Τριχόπτωση και φάρμακα για την αρθρίτιδα

[sito]

Κοιτάξτε εδώ:
http://www.hairsite.com/hair-loss/forum_entry-id-85302.html

This is a new thread to discuss 3 cases in which it seems rheumatroid arthritis drugs restored hair.

What is interesting about these 3 cases is that:

1) growth of hairs was over an area of scalp that he
previously been devoid of visible hair

2) and the new density of new hair growth on the
scalp was equal to that on the areas of his scalp that were not subject to
balding.

3) They were male pattern baldness sufferers

this is something that sounds like a complete cure. The ultimate goal we are after. And its been done 3 times on humans. Noone else acheived anything even margnaly close to this.

First two cases are on benoxaprofen.

Third is recent report of hlh user who reported that he regrew 3cm of slick bald frontal hairline loss to full density and teen like coverage while he was taking sulfasalazine.

The timeline for these incidents were 5-9 months of continuous oral drug intake to see the regrowth. The dosages of sulfasalazine was 3000mg a day.

I already posted 2 related threads where more information can be found:

benoxaprofen: http://www.hairsite.com/hair-loss/forum_entry-id-32535-page-0-category-1-order-last_answer.html

sulfasalazine and benoxaprofen: http://www.hairsite.com/hair-loss/board_entry-id-84934.html

Bellow here is a summary of my findings so far:

Both benoxaprofen an sulfasalazine have few things in common.

One is for almost sure. The drugs alone wont grow hair. I concluded this from the fact that plenty of ppl take the drugs, so if hair growth was common side effect, they would have noticed. The ultimate goal of this thread would be to find out what is the missing part that together with these drugs gave the users the pleasant side effect.

They have similar side effects (photosensitivity for example). Both are anti inflamatory drugs used to treat rheumatoic arthritis and similar diseases.

Theres also a study that says that misture of iron ions together with 5-aminolevulinic-acid 5ala (active component in sulfasalazine) grows hair in mice

http://inhumanexperiment.blogspot.com/2008/12/mixture-of-5-aminolevulinic-acid-and.html

And patent that shows growth in humans (although its not sure if these were male pattern baldness cases at all):

http://www.google.com/patents?hl=cs&lr=&vid=USPATAPP11568322&id=oE2iAAAAEBAJ&oi=fnd&dq=5-aminolevulinic+acid+%22male+pattern%22&printsec=abstract#v=onepage&q=5-aminolevulinic%20acid%20%22male%20pattern%22&f=false

The regrowth in the patent is unusualy fast (4-7 weeks).

There is some minor evidence that arthritis has to do with some lack of some bone progenitor cells (and we know that hairloss has to do with lack of hair follicle progenitor cells as well)

http://scholar.google.com/scholar?q=progenitor+arthritis

Sulfasalazine is also used to reverse fibrosis.

http://www.gastrojournal.org/article/S0016-5085%2804%2901847-5/abstract?referrer=http://scholar.google.cz/scholar?q=sulfasalazine+fibrosis&hl=cs&btnG=Hledat

We also speculated that it could be sunburn (the photosensitivity damage) + the drug that stimulates the new growth.

This is very weak hypothesis. To support it we only have a gefinitib guy case which somehow shows regrowth on areas exposed to sun (if he got sunburn from back to front). All in all, i consider this to be just speculation.

http://www.hairsite.com/hair-loss/forum_entry-id-33436.html

Although it should also be stated that the patent also suggests that opposite can be acheived (if too much of 5-ala together with photo stimulation is used, follicles can be damaged).

If we were to try topical mixture of 5-ala and iron ions or mixture based on the patents, we should probably first test it on areas where possible hairloss wont bother us (very back of our neck for example) to find out if its safe. Also both users of anti androgens and users who do not use antiandrogens at all should try to test this, because atm we dont know if that can interfere with the treatment.

Im sick of this disease. Lets try to crack this down.

Everyone who can contribute please do so. Everyone who knows anyone who is scientificaly interested or knows any hair loss site user who is especialy bright in science of hairloss, please notify them of this thread.

 

[vag25]

23.05.2011

Θα ειχε γινει ηδη χαμος

 

[sito]

23.05.2011

Θα ειχε γινει ηδη χαμος

Ναι αλλα αν το διαβασεις προσεκτικα κ αυτος το λεει οτι σιγουρα δν ειναι μονο απο αυτα τα φαρμακα γτ θα ειχε γινει ηδη γνωστο ΑΛΛΑ πρεπει να υπαρχει ΚΑΤΙ ακομα το οποιο μετα δινει την ωθηση στον θυλακα για να ποαραχθει η τριχα.... αυτο το κατι πρεπει να βρουμε.

Dr. Κος τι λες εσυ γι'αυτο;

 

[kos1987]

Η Benoxaprofen μπορει να δουλευει μεσω των proteoglycans...
H Sulfasalazine -//- της εκκρισης adenosine απο τις περιοχες που φλεγμαινουν.Συνεπως σε μας μπορει να μην δουλευει, αλλα θα το κοιταξω προσεχως, γιατι τωρα εχω κατι δουλιτσες...

 

[dk1984]

Effects of dexamethasone and sulfasalazine on prostaglandin E2 output by human placental cells in vitro.
Mirazi N, Alfaidy N, Martin R, Challis JR.
Source
Canadian Institutes for Health Research, Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVE:
Prostaglandins (PG) are key mediators of the labor process. We investigated effects of dexamethasone on PGE2 output in term human placental cells in the presence of indomethacin, an inhibitor of PGH synthase enzymes PGHS1 and PGHS2 activity; meloxicam, a relatively specific inhibitor of PGHS2; and sulfasalazine, an inhibitor of 15-OH PG dehydrogenase (PGDH), a PG-metabolizing enzyme.
METHODS:
Cells were treated for 24 hours with indomethacin (1 microM), meloxicam (1 microM), sulfasalazine (1 microM), or combinations of these three compounds in the presence or absence of glucocorticoids.
RESULTS:
Meloxicam alone had no effect on basal output of PGE2. Dexamethasone produced a significant, almost doubling of PGE2 output, but this was not altered further by meloxicam. Sulfasalazine alone doubled the output of PGE2, and this increased further in the presence of dexamethasone. That increase was reduced by addition of meloxicam. Indomethacin significantly reduced stimulation of PGE2 output measured after dexamethasone treatment. In addition, indomethacin significantly attenuated the stimulation of PGE2 output seen with the addition of sulfasalazine or the further increase seen with sulfasalazine plus dexamethasone.
CONCLUSION:
Basal PGE2 output by placental cells likely depends on the activity of PGHS1, not PGHS2. The effects of sulfasalazine suggest the importance of endogenous PGDH in regulating PGE2 output, and interactions with sulfasalazine, dexamethasone, and meloxicam suggest that glucocorticoid-stimulated output of PGE2 by placental cells may be attributable to both up-regulation of PGHS and down-regulation of PGDH
Δε ξερω αν εκανα καλα που το ανεβασα αλλα απο οτι καταλαβα διπλασιασε την pge2 στα κυτταρα του πλακουντα οποτε δεν θα εχει αποτελεσμα η εφαρμογη σαν τοπικο στα δερματικα κυτταρα?

 

[panoslydios]

απο το πρωτο post:

Sulfasalazine is also used to reverse fibrosis.

εχω βαρεθει να βλεπω τοσες αποδειξεις για την ινωση... μπορει να προκαλειται απο το συνδυασμο χιλιαδων παραγοντων
(ανδρογονα,κακη κυκλοφορια του αιματοσ στο κεφαλι για χιλιους δυο λογους,εκθεση στον ηλιο για εμας που ζουμε σε τετοια χωρα,)
...αλλα το αποτελεσμα ειναι ενα erifollicular fibrosis=ινωση γυρω απο το θυλακα...
αιτιες=χιλιες δδυο
αποτελεσμα=1 ινωση γυρω απο το θυλακα.
απο οτι εχω καταλαβει η pdg2 πορκαλει φλεγμονη που με τη σειρα της προκαλει αναπτυξη ινοβλαστων...
αυτα τα ινοβλαστα εμποδιζουν την πληρη αναγεννηση του δερματος...εκεινο το κακο κολλαγονο
που βλεπεις στις ουλες ειναι στοιβαδες απο ινοβλαστα ..
οποιος θελει να δει αποτελεσματα ας ξεκινησει απο εδω..οποιος θελει να βρει την ακριβη αιτια της τριχοπτωσης ας
γινει επιστημονας και ισως να καταλαβει οτι η ακριβης αιτια να μην βρεθει ποτε...
μια θεωρια αναγκαστικα ειναι λαθος εως οτου βγει μια αλλη που θα την καταργει με καλυτερα επιχειρηματα...
αυτο συμβαινει και για την τριχοπτωση ....η θεωρια θα εξελισσεται για χρονια και χρονια...
με λιγα λογια
REVERSE FIBROSIS!!!!!

 

[kapa]

Ναι αλλα αν το διαβασεις προσεκτικα κ αυτος το λεει οτι σιγουρα δν ειναι μονο απο αυτα τα φαρμακα γτ θα ειχε γινει ηδη γνωστο ΑΛΛΑ πρεπει να υπαρχει ΚΑΤΙ ακομα το οποιο μετα δινει την ωθηση στον θυλακα για να ποαραχθει η τριχα.... αυτο το κατι πρεπει να βρουμε.

Αυτο το κάτι λέγεται IGF1 και δίνει επανεκφυση οταν χρησιμοποιείτε τοπικα η υποδορια.

Μην ξεκινήσει κανεις τίποτα ακόμα,δεν ειναι ολα ασφαλή