Απ: SANDIMUN NEORAL (υγρό) ,έδωσε τριχοφυία
ξεχάστηκε το θέμα Neoral βρήκα αυτό
I'd opt for tacrolimus due to safety.
"Cyclosporine therapy was associated with a higher incidence of reported adverse effects. Mean arterial pressure and serum cholesterol level were significantly higher at 3 months in the cyclosporine group than the tacrolimus group.
Conclusions: Tacrolimus and cyclosporine were similar with regard to efficacy for posterior segment intraocular inflammation, but the results suggested a more favorable safety profile for tacrolimus therapy."
Regarding the study of hair follicles indicating pattern alopecia grafted onto immunodeficient mice (in which hair grew), it just points to a topical immunosuppressant or immunomodulatory (which have been discussed on HLT already). I did come across one that was discussed which a steroid user with MPB was using that reversed his hair loss..
NOTE: I am not suggesting anyone use any of these, there are inherent problems with drugs of this nature.
"Tacrolimus is the current best drug for hair loss in my opinion unfortunately it is not commonly available in topical form though the drug company Fujisawa has an NDA awaiting for tacrolimus for it's use in atopic dermatitis (eczema).
Currently the only place which carries tacrolimus is
http://www.communitydrug where it is priced at $130 for 30 mls this price will significantly drop when the official form of the drug from the manufacturer Fujisawa is FDA approved later this year.
Tacrolimus for me personally has regrown so much of the hair I have lost over the past few years making my hair loss become hardly noticeable.
In the studies it has been used at only once or twice a week I myself have opted to use it 1ml every other day.
This is the first drug which works in a way completely aside from hormonal manipulation or through the potassium k channel openers (minoxidil is a drug of this class) and is the best current way to treat hair loss."
Again, this drug I mentioned is not the route to take for MPB, but there is potential with these class of drugs or at least a specific class of inhibitors...
Regarding Tacrolimus: The long-term safety of Tacrolimus Ointment has not been determined. Because rare cases of cancer (eg, lymphoma, skin cancer) have been reported, continuous long-term use should be avoided and the application of Tacrolimus Ointment should be limited to the affected areas. Tacrolimus Ointment should not be used in children younger than 2 years of age.
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