Betamethasone dipropionate is a steroid and has a tendency to thin the dermis. All-trans-retinoic acid is also administered in combination with betamethasone dipropionate. However, one of the well-known side effects of all-trans-retinoic acid is that it acts to thicken the skin. Thus, when used in combination with each other, the negative side effects of betamethasone dipropionate and all-trans-retinoic acid act to cancel each other out while synergistically producing a large amount of hair. In the preferred embodiment, the betamethasone dipropionate and all-trans-retinoic acid are applied in combination with each other as a topical preparation in the form of a gel. The ratio of betamethasone dipropionate to all-trans-retinoic acid ranges from 1:1 to 15:1, with 4:1 being the preferred ratio.
Initially, the user should apply the salve of the present invention once a day. Applicant's experimental data has disclosed that by doubling the amount of betamethasone dipropionate while leaving unchanged the amount of all-trans-retinoic acid, (i.e., from a 2:1 to a 4:1 ratio) a significant increase in the efficacy of the salve is achieved. The salve of the present invention may be provided in the form of a gel, an ointment, a cream, or a liquid.
EXAMPLE 1
In the preferred embodiment of the compound, a topical gel was formed having betamethasone dipropionate and all-trans-retinoic acid as main active ingredients. The gel is made in 4800 g batches. 600 mg of pure all-trans-retinoic acid powder, 1200 mg of pure betamethasone dipropionate powder, 2400 g of 0.05% betamethasone dipropionate lotion (available from Lemmon Laboratory in Sellersville, Pa.) and 2400 g of Liqua-Gel™ (available from Paddock Laboratory in Minneapolis, Minn.) were weighed out on an analytical balance. The all-trans-retinoic acid powder and the betamethasone dipropionate powder were ground together with a mortar-and-pestle. The betamethasone dipropionate lotion and the Liqua-Gel were then added to the ground powders in order to put them into suspension. The resulting compound contains 0.05% by weight betamethasone dipropionate and 0.0125% by weight all-trans-retinoic acid, for a corticosteroid-to-Vitamin A derivative ratio of 4:1.
The gel was applied to the scalp of a patient diagnosed with male-pattern baldness. The patient had scar tissue on the scalp resulting from scalp reduction surgery. The gel was applied in a thin layer to the patient's scalp once per day. Visible hair re-growth around the periphery of the hairless area was evident after one month. After four months, virtually all of the previous hairless area was covered with hair, with new hair growth covering through scar tissue.
EXAMPLE 2
The same protocol as outlined in Example 1 was followed, except the resulting compound contained 0.025% by weight betamethasone dipropionate and 0.0125% by weight all-trans-retinoic acid, or a corticosteroid-to-Vitamin A derivative ratio of 2:1.
This compound was found to be about half as effective on patients suffering from hair loss, as compared to the compound containing a 4:1 ratio of betamethasone dipropionate to all-trans-retinoic acid, which was found to be 100% effective on patients suffering from hair loss for any reason whatsoever.
In patients for which the compound containing a 2:1 ratio of betamethasone dipropionate to all-trans-retinoic acid was effective, the compound took approximately three to four times as long to show visible results of hair growth as the compound containing a 4:1 ratio. Finally, the compound containing the 2:1 ratio did not dissolve scar tissue.
The gel is applied to the affected scalp once a day. Since any excess gel will dry on the scalp and flake, the gel should be applied in as thin a coat as possible. Although it is possible to rub the gel into affected portions of the scalp, it is not necessary to do so, as it has been found that mere contact by the gel with the scalp produces desired results. Outstanding results, including hair growth within one week of applying the compound, were observed. It is believed that treatment will be successful with other proportions of the active ingredients, as well as different combinations of a corticosteroid in combination with a Vitamin A derivative.
It is believed that the corticosteroid and the Vitamin A derivative work synergistically together to cancel out the harmful side effects of each other in order to rejuvenate the hair follicles in the scalp.
It is understood, of course, that the invention is not limited to the particular embodiments described herein. For instance, it is within the contemplation of the invention to use any corticosteroid or any Vitamin A derivative, and the proportions described may be varied.
περισσότερα εδω http://www.freepatentsonline.com/6344448.html
Betamethasone dipropionate = PROPIOFORM/Schering: cr.ext.us 0.05% x 15 g = 1ευρω
εφτιαξα ενα blog να στελνω την προοδο μου εδω για οποιον θελει να δει τι κανει ο βομαρδισμος με μινοξ και τρετινοινη στους κροταφους
http://andreaszam.blogspot.com/2009/12/my-hair-loss-progress.html
Initially, the user should apply the salve of the present invention once a day. Applicant's experimental data has disclosed that by doubling the amount of betamethasone dipropionate while leaving unchanged the amount of all-trans-retinoic acid, (i.e., from a 2:1 to a 4:1 ratio) a significant increase in the efficacy of the salve is achieved. The salve of the present invention may be provided in the form of a gel, an ointment, a cream, or a liquid.
EXAMPLE 1
In the preferred embodiment of the compound, a topical gel was formed having betamethasone dipropionate and all-trans-retinoic acid as main active ingredients. The gel is made in 4800 g batches. 600 mg of pure all-trans-retinoic acid powder, 1200 mg of pure betamethasone dipropionate powder, 2400 g of 0.05% betamethasone dipropionate lotion (available from Lemmon Laboratory in Sellersville, Pa.) and 2400 g of Liqua-Gel™ (available from Paddock Laboratory in Minneapolis, Minn.) were weighed out on an analytical balance. The all-trans-retinoic acid powder and the betamethasone dipropionate powder were ground together with a mortar-and-pestle. The betamethasone dipropionate lotion and the Liqua-Gel were then added to the ground powders in order to put them into suspension. The resulting compound contains 0.05% by weight betamethasone dipropionate and 0.0125% by weight all-trans-retinoic acid, for a corticosteroid-to-Vitamin A derivative ratio of 4:1.
The gel was applied to the scalp of a patient diagnosed with male-pattern baldness. The patient had scar tissue on the scalp resulting from scalp reduction surgery. The gel was applied in a thin layer to the patient's scalp once per day. Visible hair re-growth around the periphery of the hairless area was evident after one month. After four months, virtually all of the previous hairless area was covered with hair, with new hair growth covering through scar tissue.
EXAMPLE 2
The same protocol as outlined in Example 1 was followed, except the resulting compound contained 0.025% by weight betamethasone dipropionate and 0.0125% by weight all-trans-retinoic acid, or a corticosteroid-to-Vitamin A derivative ratio of 2:1.
This compound was found to be about half as effective on patients suffering from hair loss, as compared to the compound containing a 4:1 ratio of betamethasone dipropionate to all-trans-retinoic acid, which was found to be 100% effective on patients suffering from hair loss for any reason whatsoever.
In patients for which the compound containing a 2:1 ratio of betamethasone dipropionate to all-trans-retinoic acid was effective, the compound took approximately three to four times as long to show visible results of hair growth as the compound containing a 4:1 ratio. Finally, the compound containing the 2:1 ratio did not dissolve scar tissue.
The gel is applied to the affected scalp once a day. Since any excess gel will dry on the scalp and flake, the gel should be applied in as thin a coat as possible. Although it is possible to rub the gel into affected portions of the scalp, it is not necessary to do so, as it has been found that mere contact by the gel with the scalp produces desired results. Outstanding results, including hair growth within one week of applying the compound, were observed. It is believed that treatment will be successful with other proportions of the active ingredients, as well as different combinations of a corticosteroid in combination with a Vitamin A derivative.
It is believed that the corticosteroid and the Vitamin A derivative work synergistically together to cancel out the harmful side effects of each other in order to rejuvenate the hair follicles in the scalp.
It is understood, of course, that the invention is not limited to the particular embodiments described herein. For instance, it is within the contemplation of the invention to use any corticosteroid or any Vitamin A derivative, and the proportions described may be varied.
περισσότερα εδω http://www.freepatentsonline.com/6344448.html
Betamethasone dipropionate = PROPIOFORM/Schering: cr.ext.us 0.05% x 15 g = 1ευρω
εφτιαξα ενα blog να στελνω την προοδο μου εδω για οποιον θελει να δει τι κανει ο βομαρδισμος με μινοξ και τρετινοινη στους κροταφους
http://andreaszam.blogspot.com/2009/12/my-hair-loss-progress.html
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