Υπάρχει ένας κινέζος που εμφανίστηκε σε ένα ξένο Φόρουμ όπου έχει δημιουργήσει μια σειρά από προϊόντα με κύριο συστατικό το chlorine dioxide όπου ισχυρίζεται ότι θεραπεύουν την ανδρογενετικού τύπου αλωπεκία, την γυροειδή αλωπεκία, την ακμή, την ψωρίαση, και την λεύκη.
Τα προϊόντα του τα έχει λανσάρει στην Κινά και αποφάσισε να στείλει ένα μεγάλο αριθμό δειγμάτων δωρεάν σε ανθρώπους από όλο τον κόσμο για να το δοκιμάσουν. Υπάρχουν και Έλληνες συμμετέχοντες μεταξύ τον οποίον είμαι και εγώ. Έχει κάνει κάποια μακροσκελή post για το προϊόν της ανδρογενετικής αλωπεκίας και αναφέρω συνοπτικά τα σημαντικότερα.
Causes of baldness:
----------------------
Excessive DHT accumulated on the scalp will lead to swelled sebaceous gland.
Thus, on one hand, the swelled sebaceous gland will compress hair follicle cells, and on the other hand, it will produce excessive grease.
The compression to the hair follicle cells means that the sebaceous gland and the hair follicle cells struggle for living spaces.
How and why Minoxidil works (to some extent):
------------------------------------------------------
if hair follicles are squeezed, blood vessel supplying blood to the hair follicles will be influenced, i.e., nutritional supplements will be insufficient, and thus hairs cannot naturally continue grow, just like that if no fertilizers, crops will not better grow up. The second aspect can be further proved by actual effects of another medicament, i.e., minoxidil. The minoxidil is initially used for expanding blood vessels, but it has a special side-effect, i.e., to cause a hirsutism. When the minoxidil is used as a medicament for treating the alopecia, just the special side-effect is utilized. Such side-effect can be understood as that: the minoxidil will lead to blood vessel expansion, which results in that amounts of blood provided to hair follicles are increased, and nutritional supplements thereto are sufficient. Thus, the hair-developing ability of the hair follicles is high to such an extent that new hairs will dash out of the squeezed exit of hair follicles to grow some fine hairs.
Why Minoxidil is not enough:
---------------------------------
Although the scalp administration of the minoxidil can effectively stimulate the nutritional supply of the blood vessels, and activate hair follicle to develop new hair, the minoxidil administration does not solve the fundamental factor of alopecia, i.e., due to the presence of accumulated DHT, the sebaceous gland is rendered swelled, and the swollen sebaceous gland in turn oppress hair follicles and new hairs. Hence, the minoxidil can stimulate the development of new hair from hair follicles, but cannot completely change the environments lead to the alopecia, so that the minoxidil exert its effects slowly.
Why Finasteride works (to some extent):
----------------------------------------------
finasteride is a 4-aza steroidal compounds, which is a specific inhibitor to intracellular enzyme-II type 5?-redutase during the metabolism of testosterone into the stronger DHT, but it is invalid for type I 5?-redutase.This drug can reduce DHT near blood and scalp, and can promote growth of new hairs in the alopecia area.
Why Finasteride is not enough:
-----------------------------------
Just because the effective ingredient which can reach the scalp is less by oral administration of the finasteride, and the finasteride is only effective to the II-type 5?-redutase, the action of eliminating DHT is poor, so that the long time administration is required. Because of the slow effects, the long time administration is required, which in turn, will lead to the risk of side-effects.
So what we need is ... :
---------------------------
To sum up, in order to more effectively treat alopecia, it is necessary to directly administrate drugs in the vicinity of the scalp, and the corresponding effects are more direct, with no systemic effects. In addition, an externally-used mixed solution effective to treat the alopecia should have the following important effects: (1) inhibiting 5a-reducase; (2) eliminating DHT (thereby allaying the swelling of the sebaceous gland); (3) enhancing the drug permeability (drugs must permeate into the scalp); (4) anti-inflammation and anti-dandruff; (5) increasing the nutritional supply to hair follicles (for example, the minoxidil can expand blood vessels, thereby increasing nutritional supply); (6) stimulating hair follicle regeneration (a lot of hair follicles may have no activity, the regeneration can save the hair follicles).
In comes the Chlorine Dioxide:
-----------------------------------
chlorine dioxide can inhibit 5alpha-reductase, thereby eliminating DHT; chlorine dioxide can also stimulate the development of new hairs from hair follicle, and it has the action of removing scurf. However, due to a low concentration, the maximum effect of the chlorine dioxide cannot be exerted, and the hair-growing effects cannot be significantly improved.
This is the mix they propose:
------------------------------------
A hair-growth-promoting solution containing chlorine dioxide, made from the following components in weight percentage: chlorine dioxide or chlorine dioxide precursor 0.1-7.5, dimethyl sulfoxide 0-30, lycium barbarum polysaccharides 0-20, flax lignan0-20, sodium chloride 0-1.5, a conditioner 0-20, a proper amount of a pH regulator to regulate the pH value to 1.5-4.5, supplemented with deionized water to 100.
In the aforementioned solution, the chlorine dioxide precursor may be sodium chlorite, potassium chlorite, calcium chlorite, magnesium chlorite or barium chlorite, and preferably sodium chlorite.
In the aforementioned solution, the pH regulator may be one or more of citric acid, acetic acid, glycolic acid, salicylic acid, boric acid, sodium dihydrogen phosphate or lactic acid, and preferably citric acid.
In the aforementioned solution, the conditioner is one or more of sodium citrate, aloe extract, or vitamin B.
A method for preparing the aforementioned hair-growth-promoting solution containing chlorine dioxide, comprises the following step: deionized water is taken in a proportional amount, and lycium barbarum polysaccharides, flax lignan, a conditioner and sodium chloride are added thereto; the resultant mixture is heated to 60-75?, with stirring to make them be completely dissolved; then the mixture is cooled to 30? or less, and then chlorine dioxide gas or chlorine dioxide precursor is introduced; after stirring, the pH of the mixed solution is adjusted with a pH regulator to be 1.5 to 4.5.
How to apply:
------------------
Once every day (as performed in their limited clinical test). The hair-growth-promoting solution containing chlorine dioxide is taken out from a sealed container and placed in a glass or plastic cup; subsequently, the solution is dipped with a cotton swab and then is smeared on the alopecia area, and after waiting for 1 to 2 hours, the head is washed with water.
What 'they' claim:
----------------------------
The final mixed solution can achieve the ideal effect of rapidly developing hairs, so that the alopecia sufferers can be cured without a long time administration.
(limited) Clinical testing:
-----------------------------------
There are 43 male alopecia sufferers (ages: from 22 to 68) which use this mix.
98% : After 3 to 5 day upon the administration, new hairs grown on the alopecia area, like stubbles when feeling with hands and visible to naked eyes, and the new hairs are tough healthy hairs Due to the administration on the scalp, the effect of the product is exerted quickly. The hair-growth-promoting solution can completely remove factors causing the hair loss, stimulate the hair follicles, and allay the swelling of sebaceous gland, so that new hairs can smoothly grow.
100% : After 2 to 6 upon the administration, hairs on the alopecia area rapidly shed, in which fine hairs firstly shed. The more serious the alopecia is, the more the hair loss is. For the 4+ grade alopecia sufferer, after six days, all hairs in the initial alopecia area shed completely. Among the remaining hairs in the alopecia area, the proportion of hairs in the catagen phase and the telogen phase are higher, and with the alopecia is more serous, the proportion will be gradually near to 100%; after the use of the hair-growth-promoting solution, the hair follicles develop new healthy hairs, to push out hairs in the catagen phase and the telogen phase, and the exhibited phenomena is that the hairs shed more rapidly.
93% After 15 to 25 days upon the administration (once each day), new hairs visible to naked eyes grow up; For mild alopecia sufferer, hair lines obviously move forward. As to some of hair follicles, the stimulating effect of the hair-growth-promoting solution will lag for several days, and the exhibited phenomena is that hair follicles which do not contain hairs initially develop first hairs; under the action of the hair-growth-promoting solution, some hair follicles develop second hairs.
81% After first course of treatment with the administration, it can be judged by naked eyes that hairs restore to the next grade, for example, 2-grade hairs restore to 1-grade hairs, 4-grade hairs restore to 3-grade hairs. After 1 to 2 months, the second course of the treatment begins, and it can be judged by naked eyes that hairs restore to further next grade. First course of treatment will cost 15 to 25 days, and after the course, new hairs grow up. During the withdraw of the drug, if no new hairs are developed in 10 days (judged by hands or naked eyes), the second course of the treatment begins, and the second course will cost 10 to 15 days, and the like
Τα προϊόντα του τα έχει λανσάρει στην Κινά και αποφάσισε να στείλει ένα μεγάλο αριθμό δειγμάτων δωρεάν σε ανθρώπους από όλο τον κόσμο για να το δοκιμάσουν. Υπάρχουν και Έλληνες συμμετέχοντες μεταξύ τον οποίον είμαι και εγώ. Έχει κάνει κάποια μακροσκελή post για το προϊόν της ανδρογενετικής αλωπεκίας και αναφέρω συνοπτικά τα σημαντικότερα.
Causes of baldness:
----------------------
Excessive DHT accumulated on the scalp will lead to swelled sebaceous gland.
Thus, on one hand, the swelled sebaceous gland will compress hair follicle cells, and on the other hand, it will produce excessive grease.
The compression to the hair follicle cells means that the sebaceous gland and the hair follicle cells struggle for living spaces.
How and why Minoxidil works (to some extent):
------------------------------------------------------
if hair follicles are squeezed, blood vessel supplying blood to the hair follicles will be influenced, i.e., nutritional supplements will be insufficient, and thus hairs cannot naturally continue grow, just like that if no fertilizers, crops will not better grow up. The second aspect can be further proved by actual effects of another medicament, i.e., minoxidil. The minoxidil is initially used for expanding blood vessels, but it has a special side-effect, i.e., to cause a hirsutism. When the minoxidil is used as a medicament for treating the alopecia, just the special side-effect is utilized. Such side-effect can be understood as that: the minoxidil will lead to blood vessel expansion, which results in that amounts of blood provided to hair follicles are increased, and nutritional supplements thereto are sufficient. Thus, the hair-developing ability of the hair follicles is high to such an extent that new hairs will dash out of the squeezed exit of hair follicles to grow some fine hairs.
Why Minoxidil is not enough:
---------------------------------
Although the scalp administration of the minoxidil can effectively stimulate the nutritional supply of the blood vessels, and activate hair follicle to develop new hair, the minoxidil administration does not solve the fundamental factor of alopecia, i.e., due to the presence of accumulated DHT, the sebaceous gland is rendered swelled, and the swollen sebaceous gland in turn oppress hair follicles and new hairs. Hence, the minoxidil can stimulate the development of new hair from hair follicles, but cannot completely change the environments lead to the alopecia, so that the minoxidil exert its effects slowly.
Why Finasteride works (to some extent):
----------------------------------------------
finasteride is a 4-aza steroidal compounds, which is a specific inhibitor to intracellular enzyme-II type 5?-redutase during the metabolism of testosterone into the stronger DHT, but it is invalid for type I 5?-redutase.This drug can reduce DHT near blood and scalp, and can promote growth of new hairs in the alopecia area.
Why Finasteride is not enough:
-----------------------------------
Just because the effective ingredient which can reach the scalp is less by oral administration of the finasteride, and the finasteride is only effective to the II-type 5?-redutase, the action of eliminating DHT is poor, so that the long time administration is required. Because of the slow effects, the long time administration is required, which in turn, will lead to the risk of side-effects.
So what we need is ... :
---------------------------
To sum up, in order to more effectively treat alopecia, it is necessary to directly administrate drugs in the vicinity of the scalp, and the corresponding effects are more direct, with no systemic effects. In addition, an externally-used mixed solution effective to treat the alopecia should have the following important effects: (1) inhibiting 5a-reducase; (2) eliminating DHT (thereby allaying the swelling of the sebaceous gland); (3) enhancing the drug permeability (drugs must permeate into the scalp); (4) anti-inflammation and anti-dandruff; (5) increasing the nutritional supply to hair follicles (for example, the minoxidil can expand blood vessels, thereby increasing nutritional supply); (6) stimulating hair follicle regeneration (a lot of hair follicles may have no activity, the regeneration can save the hair follicles).
In comes the Chlorine Dioxide:
-----------------------------------
chlorine dioxide can inhibit 5alpha-reductase, thereby eliminating DHT; chlorine dioxide can also stimulate the development of new hairs from hair follicle, and it has the action of removing scurf. However, due to a low concentration, the maximum effect of the chlorine dioxide cannot be exerted, and the hair-growing effects cannot be significantly improved.
This is the mix they propose:
------------------------------------
A hair-growth-promoting solution containing chlorine dioxide, made from the following components in weight percentage: chlorine dioxide or chlorine dioxide precursor 0.1-7.5, dimethyl sulfoxide 0-30, lycium barbarum polysaccharides 0-20, flax lignan0-20, sodium chloride 0-1.5, a conditioner 0-20, a proper amount of a pH regulator to regulate the pH value to 1.5-4.5, supplemented with deionized water to 100.
In the aforementioned solution, the chlorine dioxide precursor may be sodium chlorite, potassium chlorite, calcium chlorite, magnesium chlorite or barium chlorite, and preferably sodium chlorite.
In the aforementioned solution, the pH regulator may be one or more of citric acid, acetic acid, glycolic acid, salicylic acid, boric acid, sodium dihydrogen phosphate or lactic acid, and preferably citric acid.
In the aforementioned solution, the conditioner is one or more of sodium citrate, aloe extract, or vitamin B.
A method for preparing the aforementioned hair-growth-promoting solution containing chlorine dioxide, comprises the following step: deionized water is taken in a proportional amount, and lycium barbarum polysaccharides, flax lignan, a conditioner and sodium chloride are added thereto; the resultant mixture is heated to 60-75?, with stirring to make them be completely dissolved; then the mixture is cooled to 30? or less, and then chlorine dioxide gas or chlorine dioxide precursor is introduced; after stirring, the pH of the mixed solution is adjusted with a pH regulator to be 1.5 to 4.5.
How to apply:
------------------
Once every day (as performed in their limited clinical test). The hair-growth-promoting solution containing chlorine dioxide is taken out from a sealed container and placed in a glass or plastic cup; subsequently, the solution is dipped with a cotton swab and then is smeared on the alopecia area, and after waiting for 1 to 2 hours, the head is washed with water.
What 'they' claim:
----------------------------
The final mixed solution can achieve the ideal effect of rapidly developing hairs, so that the alopecia sufferers can be cured without a long time administration.
(limited) Clinical testing:
-----------------------------------
There are 43 male alopecia sufferers (ages: from 22 to 68) which use this mix.
98% : After 3 to 5 day upon the administration, new hairs grown on the alopecia area, like stubbles when feeling with hands and visible to naked eyes, and the new hairs are tough healthy hairs Due to the administration on the scalp, the effect of the product is exerted quickly. The hair-growth-promoting solution can completely remove factors causing the hair loss, stimulate the hair follicles, and allay the swelling of sebaceous gland, so that new hairs can smoothly grow.
100% : After 2 to 6 upon the administration, hairs on the alopecia area rapidly shed, in which fine hairs firstly shed. The more serious the alopecia is, the more the hair loss is. For the 4+ grade alopecia sufferer, after six days, all hairs in the initial alopecia area shed completely. Among the remaining hairs in the alopecia area, the proportion of hairs in the catagen phase and the telogen phase are higher, and with the alopecia is more serous, the proportion will be gradually near to 100%; after the use of the hair-growth-promoting solution, the hair follicles develop new healthy hairs, to push out hairs in the catagen phase and the telogen phase, and the exhibited phenomena is that the hairs shed more rapidly.
93% After 15 to 25 days upon the administration (once each day), new hairs visible to naked eyes grow up; For mild alopecia sufferer, hair lines obviously move forward. As to some of hair follicles, the stimulating effect of the hair-growth-promoting solution will lag for several days, and the exhibited phenomena is that hair follicles which do not contain hairs initially develop first hairs; under the action of the hair-growth-promoting solution, some hair follicles develop second hairs.
81% After first course of treatment with the administration, it can be judged by naked eyes that hairs restore to the next grade, for example, 2-grade hairs restore to 1-grade hairs, 4-grade hairs restore to 3-grade hairs. After 1 to 2 months, the second course of the treatment begins, and it can be judged by naked eyes that hairs restore to further next grade. First course of treatment will cost 15 to 25 days, and after the course, new hairs grow up. During the withdraw of the drug, if no new hairs are developed in 10 days (judged by hands or naked eyes), the second course of the treatment begins, and the second course will cost 10 to 15 days, and the like
