How finasteride affects male fertility
Finasteride is one of a number of
medications that may reduce fertility.
Finasteride is one of a number of
medications that may reduce fertility.
According to
recent research, this might occur through finasteride interfering with the hormone prostaglandin. Prostaglandin is
linked to calcium, or Ca2+, signaling in sperm. Blocking this signaling may affect sperm functions including motility (ability to move) and capacitation (the changes that must be undertaken for sperm to fertilize an egg).
Finasteride also appears to affect sperm counts. A
small 2020 study found that within six months of starting finasteride to treat hair loss, subjects’ sperm counts and testosterone levels had decreased.
The medication doesn’t appear to impact all people equally.
Research from 2013 suggests that finasteride may be more likely to lower sperm count in those who already have other conditions that affect their fertility, compounding its effect.
Is the effect of finasteride on fertility permanent?
In some cases it appears that finasteride’s impact on fertility may be temporary. Some
research suggests that sperm counts return to normal after stopping the medication, with the study finding 11.6-fold increases on average and no decreases.
In many men, though, finasteride’s effects on sexual function and fertility may persist or possibly be irreversible. Side effects that don’t fade quickly may last for months or years. A small
2012 study examined 54 healthy young men with ongoing sexual side effects after taking finasteride. It found that 96% continued to experience side effects after approximately 14 months, with the effects qualifying as sexual dysfunction in 89% of the men.
Some men are now calling this condition post-finasteride syndrome (PFS). A
2018 research article noted that the prevalence of PFS is unknown and needs further attention, along with treatment recommendations. Even as
recently as 2020, the syndrome has not really been acknowledged by the medical community, despite men increasingly experiencing long-lasting adverse effects. Based on available research, the author concluded that PFS may affect a subset of susceptible men, but that more research needs to be completed.
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