παιδια δεν ξερω αν εχει ειπωθει(αλλα δν μπορω να διαβασω 59 σελιδες)
αλλα υπαρχει αποψη στο hairlosshelp για τη μη χρησημοποιηση cetrizine...
PGD2 in hair follicles is not caused by HPGDS - hematopoietic prostaglandin D synthase BUT, by LPGDS lipocalin pgds.
Source? read the 22 march study of DR. cots. LPGds levels are highly elevated....
http://www.ncbi.nlm.nih.gov/pm...bin/nihms366359f2.jpg
Increased PGD2 pathway activity in balding scalp of men with AGA. (A) Expression of lipocalin-type PTGDS mRNA in bald versus haired scalp, as tested by qPCR. Data are means ± SEM (n = 4). (B and C) The amount of PTGDS protein in paired bald (B) and haired (H) scalps (n = 4), as shown by Western blotting with Ponceau stain used for verification of equal loading (B) and its quantitation as normalized to haired scalp (C). Data are means ± SEM. (D) PGD2 production in bald scalp, as tested by ELISA. Data are means ± SEM (n = 3). (E and F) Fold change in PGD2 (n = 17), 15-dPGJ2) (n = 7), and PGE2 (n = 17) expression in bald scalp compared to haired scalp (E). Total prostaglandin content is quantified in (F). Data are means ± SEM. *P < 0.05; **P < 0.01. In (F), P value compares haired versus bald samples for each prostaglandin.
knowing this, explain why cetrizine and other mastcell stabilizers, will NOT help against the elevated PGD2 in hairflocles..
so your basically missing the boat with hpgds stabilizers.